Osteoporosis: Calcium and Magnesium
Objective: We aimed to test whether the association of colorectal polyps with intake of calcium, magnesium, or both and ThrIle polymorphism in the TRPM7. Magnesium and calcium metabolism are closely related. The intestinal absorption and the renal excretion of the two ions are interdependent. The relationship. UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and.
This finding has led researchers to encourage a moderate protein intake at the RDA.
Magnesium and Calcium Absorption
Other vitamins that interact with calcium include sodium increases lossespotassium reduces lossesand magnesium, which is discussed below. Excessive caffeine, oxalic acids — found in spinach, rhubarb, and sweet potatoes — along with phytic acid may also reduce the absorption of calcium 4. How much calcium is too much? This condition is more commonly seen in chronic high-dose calcium supplementation and is characterized by high calcium in the blood and kidney failure 1.
What foods contain calcium? Calcium and disease Cancer A growing body of research has emerged raising concern about the link between dairy products and prostate cancer 1. The results of a systematic review and meta-analysis showed that high intakes of dairy, total milk, whole milk, low-fat milk, cheese, and dairy calcium was associated with a modest, but significant risk of prostate cancer 5.
- Effect of magnesium on phosphorus and calcium metabolism.
- The Importance of Dietary Calcium and Magnesium
This study did not find an association between plant-based milks or calcium supplements and the risk for prostate cancer 5. The association between dairy products, calcium supplementation, and colorectal cancer is not as clear, with some studies showing a benefit of dairy products or calcium supplementationwith others failing to find any association 9, Cardiovascular Disease Earlier studies have raised concerns that calcium supplements increase the risk of cardiovascular disease.
However, the results of a recent systematic review and meta analysis concluded that calcium intakes that did not exceed the upper limit for calcium, from either supplements or food, were not associated with an increased risk of cardiovascular disease Regardless, it may be wise to err on the side of caution, aiming for an intake that meets, but doe not exceed the RDA for calcium, until more research becomes available.
Magnesium What is magnesium and why do I need it? Magnesium is involved in more than reactions in the body, assisting in the release of energy from fat and carbohydrates, helping with DNA production, supporting nerve impulses, muscle contractions, as well as normal heart rhythms, facilitating cellular communication, and providing structure to bones and body tissues Estimates suggest that almost half of the US population is not meeting recommended requirements for magnesium, with the lowest levels of intake being found among the elderly Older adults are believed to be disproportionately affected due to low dietary intake of magnesium, reduced absorption, and increased urinary losses Overt magnesium deficiency is rare in developed countries, but is more commonly seen in specific conditions, including gastrointestinal disorders, renal disease, diabetes, and alcoholism When magnesium deficiency has been experimentally induced in humans, tremor, muscle spasms, loss of appetite, nausea, vomiting, and personality changes occurred In addition, magnesium deficiency also disrupts calcium balance, which can exaggerate vitamin D deficiency How much magnesium do I need each day?
Requirements for adults and children were set following balance studies that aimed to match intake to losses Nutrients that interact with magnesium Like calcium, many nutrients and food components can interfere with magnesium. In addition, magnesium status is impacted by too little or too much protein, warranting intake around the RDA Their foods consist primarily of green vegetables, grains, tofu, and seafood, and are twice as high in magnesium as our average diets.
Calcium causes muscles to contract, while magnesium helps them relax. When calcium is taken for menstrual cramps it knocks magnesium out of the cells and makes it more available for immediate use.
However, it depletes the body of magnesium and ensures that the problem will recur the following month unless sufficient magnesium is added to the diet. Taking calcium gives temporary relief of menstrual cramps.
A diet high in dairy and low in whole grains can lead to excess calcium in the tissues and a magnesium deficiency. The source of menstrual cramps may be coming from eating too much cheese, yogurt, ice cream or milk, combined with insufficient whole grains and beans.
Or it could come from taking too much calcium without enough magnesium. Modifying your diet and increasing your magnesium supplementation may allow your menstrual cramps to disappear. Premenstrual chocolate craving is a phenomenon that has puzzled a great many women who are not controlled by this overwhelming urge at other times of the month. Yet chocolate, which is highest in magnesium of all foods, is often a sign of magnesium deficiency.
If your diet is high in calcium you may have poor calcium absorption as well.
Effect of magnesium on phosphorus and calcium metabolism.
The answer is not to eat more chocolate, but to increase your magnesium by eating more whole grains, nuts, seafood, and green vegetables, and by increasing your magnesium supplements. Your chocolate cravings will vanish when you have enough magnesium in your diet. Mildred Seelig, executive president of the American College of Nutrition, we need an average of mg.
Foods highest in magnesium are nuts especially almonds and cashewswhole grains, seafood, and legumes including tofu. Eat more of these, while reducing sugar and alcohol, which increase magnesium excretion. Don't overlook one vitamin or mineral for another since all work together to supply you with the nutrients you need. And consult your nutritionally- oriented physician about all nutrients before trying them.
A balanced diet of fresh, whole foods is your best maintenance diet. But if you have been taking large amounts of calcium and ignoring magnesium you may want to reverse the proportions until you achieve a better balance. Therefore, we hypothesized that a high Ca: Mg intake may exaggerate magnesium deficiency and, in turn, lead to risk of colorectal cancer.
In a recent study, a missense variant [Thr to isoleucine Ile ] in the TRPM7 gene was not identified in controls, but was identified only in cases of Guamanian amyotrophic lateral sclerosis and parkinsonism dementia, both of which conditions have been linked to severe environmental deficiency of calcium and magnesium Therefore, we postulated that people who carry the variant Ile allele may be at a high risk of magnesium deficiency and, in turn, of colorectal neoplasia and other chronic diseases common in the Western populations, particularly if the Ca: Mg intake is high.
To test these hypotheses, we used data from the Tennessee Colorectal Polyp Study to investigate whether the association of colorectal adenomatous and hyperplastic polyps with the intakes of calcium and magnesium or with the ThrIle polymorphism in the TRPM7 gene may be modified by the Ca: Colorectal adenoma cases and polyp-free controls were recruited between February 1,and December 31, Excluded from our study were patients who had genetic colorectal cancer syndromes eg, hereditary nonpolyposis colorectal cancer or familial adenomatous polyposisinflammatory bowel disease, or a history of adenomatous polyps or any cancer other than nonmelanoma skin cancers.
Osteoporosis: Calcium and Magnesium
Written informed consent was obtained from all subjects. On the basis of the colonoscopy and pathology findings, participants were assigned as an adenoma case or polyp-free control. To be diagnosed as a control, the participant must have had a complete colonoscopy reaching the cecum and must have been polyp free at colonoscopy.
We found that the intakes of energy and major nutrients did not differ significantly. For example, in NHANES III, the average daily intake from diet only is kcal for total energy, mg for calcium, and mg for magnesium, whereas, in the current study, the intakes of energy, calcium, and magnesium by controls from diet only are kcal, mg and mg, respectively.
The FFQ also contains 5 items that survey eating habits and 13 items for capturing vitamin and supplement use including B vitamins, calcium, and multivitamins. Calcium and magnesium intakes from calcium and multivitamin supplements were also taken into account by estimating intake on the basis of the most common ingredients in calcium and multivitamin supplements mg Ca per calcium supplement pill and mg Ca and mg Mg per multivitamin pill.
Excluded from the analyses were 19 adenoma cases, 4 hyperplastic polyp cases, and 33 controls with unreasonably high or low energy intake. As a result, a total of adenoma cases, hyperplastic polyp cases, and adenoma-free controls were included in the final analyses.
The laboratory staff was blind to the identity of the subjects.