Relationship between prolactin and thyroid

relationship between prolactin and thyroid

There was no correlation between the serum TSH and prolactin level. the relationship between subclinical hypothyroidism, hyperprolactinemia and sterility (9). the association between Thyroid disorders and serum. Prolactin levels in infertility. So, the aim of this study was to evaluate the status of Thyroid. utes to increased prolactin concentration. This suggests that a correlation exists between hypothyroidism and hyperprolactinemia due to TRH [6]. Some studies.

Thyroid dysfunction interferes with different facets of multiplication and pregnancy. A few reviews uncover the relationship of hypo and hyperthyroidism with the menstrual aggravation, diminished fertility and increase risk of morbidity during pregnancy [ 5 - 7 ].

Hyperprolactinemia in association with subclinical hypothyroidism

Hyperprolactinemia antagonistically influences the fertility potential by disabling the pulsatile secretion of the GnRH and consequently meddling with ovulation [ 8 ]. The disorder has been initiated in the menstrual and ovulatory malfunctioning like anovulation, amenorrhea and galactorrhea [ 910 ]. Apart from this group the infertile women with consistent mensus additionally have hyperprolactinemia.

The point of the review was to discover the relationship of hyperprolactinemia that causes female infertility and it corresponds with hypothyroidism. Methods The study focus a cross-sectional approach on women who were experiencing the cause of infertility and was obtained and referred to the department of biochemistry of Dr. Essa research center establishment at Karachi, Pakistan.

relationship between prolactin and thyroid

The patients were enrolled for a period of 5 years that is from to The inclusion criteria was cases with a diagnosis of primary infertility and span of marriage over 1 years. The patients were selected after the written informed consent.

Hyperprolactinemia in association with subclinical hypothyroidism

The exclusion criteria that was considered for our study was infertility aspect of male and among the tubal elements, any prominent organic lesion and any inborn abnormality of the urogenital tract were taken as the exclusion criteria for our study. Likewise, history of thyroid illness, past thyroid surgery or on thyroid medicines was additionally added to exclusion for the study. The surgery to remove these tumors usually a transsphenoidal surgery.

Surgical success rates are highly dependent upon the experience of the neurosurgeon.

Prolactin Disorders - Houston Thyroid and Endocrine Specialists

Surgery restores prolactin concentrations to normal more often in microprolactionomas than in macroprolactinomas. One of the rare complications of this type of surgery include hypopituitarism which is a loss of all the hormones produced by the pitiutary. When a mild prolactin elevation is found, physiologic, pathologic, iatrogenic, and other endocrine causes need to be excluded before making the diagnosis of a small prolactin-secreting tumor since MRI of the pituitary can sometimes have incidental pituitary lesions.

Very high prolactin levels in are almost always indicative of a prolactin-secreting tumor called prolactinomas, except during pregnancy. Elevated prolactin levels cause galactorrhea and suppress the hypothalamic-pituitary-gonadal axis, which results in hypogonadism and a progressive decrease in the bone mineral density.

relationship between prolactin and thyroid

Untreated prolactin-secreting tumors usually grow slowly but there are exceptions. It was mentioned that hypothyroidism and hyperprolactinemia have effective roles in stimulating androgenic alopecia, this may be a probable reason for our female androgenic alopecia.

Hyperprolactinemia stimulates androgen production from adrenal and thyroxin effects on free and total testosterone with effect on thyroid binding globulin TBG. So, coexistence of these two disorders can cause intensive alopecia. In this study, the comparison of symptoms between two groups with TSH higher and lower than 10 showed no statistical difference. Other study showed that hypothyroidism symptoms were more prevalent in patients with higher TSH 5.

relationship between prolactin and thyroid

In our study, patients with TSH lower than 10 was In this study no correlation was found between TSH and prolactin levels 162123 like the results of other studies. As we expected, TRH caused hyper- prolactinemia in hypothyroidism, perhaps there is some unknown etiology that causes hyperprolactinemia in these patients.

In summary prevalence of hyperprolactinemia in subclinical hypothyroidism patients is considerable. Hyperprolactinemia causes reproduction disorders in women, early diagnosis and treatment of this disease is important.

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L-Thyroxine therapy in subclinical hypothyroidism. A double-blind, placebo-controlled trial. Spectrum of subclinical and overt hypothyroidism: Risk factors for cardiovascular disease in women with subclinical hypothyroidism. Subclinical hypothyroidism and the risk of coronary heart disease: Thyrotropin-releasing hormone TRH and metoclopramide testing in infertile women.

relationship between prolactin and thyroid

Episodic variations of prolactin, thyroid-stimulating hormone, luteinizing hormone, melatonin and cortisol in infertile women with subclinical hypothyroidism. Screening for hypothyroidism in infertile women.

relationship between prolactin and thyroid

Prevalence of subclinical hypothyroidism in a population living in the Milan metropolitan area.